The authors further concluded that beta class phenotypes represent homozygosity for one of the epsilon alleles, e.g., beta-II results from homozygosity for the epsilon-II allele. The alleles were designated epsilon-II, -III, and-IV. (1981) concluded that a single locus with 3 common alleles is responsible for these patterns. Three subclasses of each pattern were found and designated alpha-II, alpha-III and alpha-IV and beta-II, beta-III and beta-IV. Apolipoprotein E (apoE) of very low density lipoprotein (VLDL) from different persons shows 1 of 2 complex patterns, termed alpha and beta ( Zannis et al., 1981). They concluded that this polymorphism of apolipoprotein E in human serum is determined by 2 autosomal codominant alleles, apoE(n) and apoE(d).įurther complexities of the genetics of the apolipoprotein E system were discussed by Utermann et al. (1979) described 2 phenotypes, apoE(IV+) and apoE(IV-), differentiated by analytical isoelectric focusing. Mature apoE is a 299-amino acid polypeptide. (1982) published the full amino acid sequence of apoE.
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